Login / Signup

Clinical importance of FANCD2, BRIP1, BRCA1, BRCA2 and FANCF expression in ovarian carcinomas.

Joanna Moes-SosnowskaIwona K RzepeckaJoanna ChodzynskaAgnieszka Dansonka-MieszkowskaLukasz Michael SzafronAneta BalabasRenata LotockaPiotr SobiczewskiJolanta Kupryjanczyk
Published in: Cancer biology & therapy (2019)
Our study shows for the first time that FANCD2 overexpression is a strong negative prognostic factor in ovarian cancer, particularly in patients treated with TP regimen. Moreover, increased mRNA level of the BRIP1 is a negative prognostic factor in the PC-treated patients. Next, changes in the BRCA2 and BRIP1 genes are rare and together with other analyzed FA genes considered as homologous recombination deficiency may not affect the expression level of analyzed genes.
Keyphrases