KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas.
Fanny ChasseloupDaniela RegazzoLucie ToscaAlexis ProustEmmanuelle KuhnMirella HageChristel JublancKarima MokhtariMattia Dalle NogareSerena AvalloneFilippo CeccatoGerard TachdjianSylvie SalenaveJacques YoungStephan GaillardFabrice ParkerAnne-Laure BochPhilippe ChansonJerome BouligandGianluca OcchiPeter KamenickỷPublished in: European journal of endocrinology (2024)
Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.