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KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas.

Fanny ChasseloupDaniela RegazzoLucie ToscaAlexis ProustEmmanuelle KuhnMirella HageChristel JublancKarima MokhtariMattia Dalle NogareSerena AvalloneFilippo CeccatoGerard TachdjianSylvie SalenaveJacques YoungStephan GaillardFabrice ParkerAnne-Laure BochPhilippe ChansonJerome BouligandGianluca OcchiPeter Kamenickỷ
Published in: European journal of endocrinology (2024)
Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.
Keyphrases
  • poor prognosis
  • genome wide
  • gene expression
  • binding protein
  • high throughput
  • growth hormone
  • long non coding rna
  • transcription factor
  • case report
  • oxidative stress
  • dna methylation
  • copy number
  • heat shock
  • heat stress