Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score.

Lasse PihlstromChun C FanOleksandr FreiManuela M X TanRoshan A KarunamuniCornelis BlauwendraatSara Bandres-CigaZiv Gan OrDonald G Grossetnull nullAnders M DaleTyler M SeibertOle A Andreassen

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

We demonstrate the feasibility of a polygenic hazard approach in PD, integrating the genetic effects on disease risk and age at onset in a single model. In combination with other predictive biomarkers, the approach may hold promise for risk stratification in future clinical trials of disease-modifying therapies, which aim at postponing the onset of PD. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

clinical trial
genome wide
copy number
gene expression
systematic review
randomized controlled trial
big data
machine learning
open label