CD26 upregulates proliferation and invasion in keloid fibroblasts through an IGF-1-induced PI3K/AKT/mTOR pathway.

Yu XinPeiru MinHeng XuZheng ZhangYan ZhangYixin Zhang

Published in: Burns & trauma (2020)

CD26 can be the effective biomarker for KFs, and its expression is closely related to proliferation and invasion in keloids through the IGF-1-induced PI3K/AKT/mTOR pathway. This work provides a novel perspective on the pathological mechanisms affecting KFs and therapeutic strategies against keloids.

Keyphrases

high glucose
diabetic rats
binding protein
poor prognosis
endothelial cells
nk cells
long non coding rna
growth hormone
stress induced