Advancements in Trauma-Induced Acute Kidney Injury: Diagnostic and Therapeutic Innovations.
Sergio LassolaFrancesco CundariGiuseppe MariniFrancesco CorradiSilvia De RosaPublished in: Life (Basel, Switzerland) (2024)
Acute kidney injury following trauma impacts patient recovery critically, necessitating an integrated approach to emergency care and nephrology. This review aims to provide a comprehensive understanding of trauma-induced nephropathy, highlighting recent advancements in pathophysiological insights, diagnostic techniques, and strategic interventions. Our key findings emphasize the role of biomarkers, like Neutrophil Gelatinase-Associated Lipocalin and Liver Fatty Acid-Binding Protein, and imaging techniques, such as contrast-enhanced ultrasound, in early AKI detection. Preventive strategies, including aggressive fluid resuscitation, avoidance of nephrotoxic agents, and hemodynamic optimization, are essential for mitigating AKI progression. Integrating these approaches into trauma care frameworks aims to enhance patient outcomes and set a foundation for future research and clinical improvements.
Keyphrases
- acute kidney injury
- cardiac surgery
- healthcare
- trauma patients
- high glucose
- contrast enhanced ultrasound
- binding protein
- palliative care
- fatty acid
- quality improvement
- emergency department
- cardiac arrest
- public health
- high resolution
- drug induced
- endothelial cells
- quantum dots
- chronic pain
- mass spectrometry
- stress induced