Chemically Defined Antibody- and Small Molecule-Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis.

Samuele Cazzamalli Alberto Dal CorsoFontaine WidmayerDario Neri

Published in: Journal of the American Chemical Society (2018)

We present the first direct comparative evaluation of an antibody-drug conjugate and of a small molecule-drug conjugate for cancer therapy, using chemically defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.

Keyphrases

cancer therapy
small molecule
drug delivery
renal cell carcinoma
protein protein
emergency department
endothelial cells