Protein signature of human skin fibroblasts allows the study of the molecular etiology of rare neurological diseases.

Andreas HentschelArtur CzechUte MünchbergErik FreierUlrike Schara-SchmidtAlbert SickmannJens ReimannAndreas Roos

Published in: Orphanet journal of rare diseases (2021)

Our combined data reveal that human fibroblasts may serve as an in vitro system to study the molecular etiology of rare neurological diseases exemplified on Allgrove syndrome in an unbiased fashion.

Keyphrases

endothelial cells
gene expression
machine learning
extracellular matrix
electronic health record
genome wide
dna methylation
big data
brain injury
artificial intelligence
deep learning
subarachnoid hemorrhage
pluripotent stem cells