Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis.

Fernanda Vacante Pamela SenesiAnna MontesanoStefano PainiLivio Luzi Ileana Terruzzi

Published in: International journal of endocrinology (2019)

Our data show that METF could suppress HepG2 proliferation, through induction of cell cycle arrest at the G0/G1 phase. In addition, METF effect on the cancer microenvironment and on the IGF axis leads to the development of new METF therapeutic use in HCC treatment.

Keyphrases

cell cycle arrest
pi k akt
signaling pathway
binding protein
cell death
poor prognosis
papillary thyroid
stem cells
cell proliferation
squamous cell
growth hormone
machine learning
lymph node metastasis
combination therapy
smoking cessation
replacement therapy