Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1.
Zilong ZhaoDaqian XuZheng WangLin WangRuomei HanZhenzhen WangLujian LiaoYan ChenPublished in: Hepatology (Baltimore, Md.) (2018)
Ubiquitination modification through the coordinated action of PAQR3 with HUWE1 plays a crucial role in regulating the activity of PPARα in response to starvation. (Hepatology 2018;68:289-303).