Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance.
Seolsong KimNayoun KimSeokjae ParkYoonjeong JeonJaemeun LeeSeung-Jun YooJi-Won LeeCheil MoonSeong-Woon YuEun-Kyoung KimPublished in: Autophagy (2019)
3V: 3rd ventricle; ACAC: acetyl-Coenzyme A carboxylase; AGRP: agouti related neuropeptide; AIF1/IBA1: allograft inflammatory factor 1; AMPK: AMP-activated protein kinase; ARC: arcuate nucleus; Atg: autophagy related; Bafilo: bafilomycin A1; CAMKK2: calcium/calmodulin-dependent protein kinase kinase 2, beta; CCCP: carbonyl cyanide m-chlorophenylhydrazone; CNS: central nervous system; COX4I1: cytochrome c oxidase subunit 4I1; FFA: free fatty acid; GFAP: glial fibrillary acidic protein; HFD: high-fat diet; ICV: intracerebroventricular; LAMP2: lysosomal-associated membrane protein 2; LD: lipid droplet; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MBH: mediobasal hypothalamus; ME: median eminence; MEF: mouse embryonic fibroblast; NCD: normal chow diet; NEFM/NFM: neurofilament medium; NPY: neuropeptide Y; OL: oleic acid; POMC: pro-opiomelanocortin-alpha; PRKN/Parkin: parkin RBR E3 ubiquitin protein ligase; Rax: retina and anterior neural fold homeobox; RBFOX3/NeuN: RNA binding protein, fox-1 homolog (C. elegans) 3; RER: respiratory exchange ratio; siRNA: small interfering RNA; SQSTM1: sequestosome 1; TG: triglyceride; TSPO: translocator protein; ULK1: unc-51 like kinase 1; VCO2: carbon dioxide production; VMH: ventromedial hypothalamus; VO2: oxygen consumption.
Keyphrases
- protein kinase
- high fat diet
- binding protein
- fatty acid
- carbon dioxide
- adipose tissue
- insulin resistance
- oxidative stress
- protein protein
- cell death
- high throughput
- simultaneous determination
- pulmonary hypertension
- spinal cord
- cerebrospinal fluid
- single cell
- computed tomography
- spinal cord injury
- drug induced
- blood brain barrier
- left ventricular
- pulmonary arterial hypertension
- ionic liquid