Noninvasive Prenatal Test Results Indicative of Maternal Malignancies: A Nationwide Genetic and Clinical Follow-Up Study.
Catharina J HeesterbeekSietse M AukemaRobert-Jan H GaljaardElles M J BoonMalgorzata Ilona SrebniakKatelijne BoumanBrigitte H W FaasLutgarde C P GovaertsMariette J V HofferNicolette S den HollanderKlaske D LichtenbeltMerel C van MaarleLisanne van Prooyen SchuurmanMaartje C van RijG Heleen Schuring-BlomServi J C StevensGita Tan-SindhunataMasoud Zamani EstekiChristine E M De Die-SmuldersVivianne C G Tjan-HeijnenLidewij HennemanErik A SistermansMerryn V E Macvillenull nullPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
In 231,896 pregnant women, a low percentage (0.02%) of NIPT results were assessed as indicative of a maternal malignancy. However, when multiple chromosomal aberrations were found, the risk of a confirmed malignancy was considerably high. Referral for extensive oncologic examination is recommended, and may be guided by tumor-specific hallmarks in the NIPT profile.