Ipilimumab plus nivolumab for patients with metastatic uveal melanoma: a multicenter, retrospective study.

Yana G NajjarKristina NavrazhinaFei DingRoma BhatiaKaty TsaiKelly AbbateBarbara DurdenZeynep ErogluShailender BhatiaSong ParkAkansha ChowdharySunandana ChandraJonathan KennedyIgor PuzanovMarc ErnstoffPankit VachhaniJoseph DrabickArun SinghTan XuJessica YangRichard CarvajalDaniel MansonJohn M KirkwoodJustine CohenRyan SullivanDouglas JohnsonPauline FunchainAlexander Shoushtari

Published in: Journal for immunotherapy of cancer (2021)

Dual checkpoint inhibition yielded higher response rates than previous reports of single-agent immunotherapy in patients with mUM, but the efficacy is lower than in metastatic CM. The median OS of 15 months suggests that the rate of clinical benefit may be larger than the modest response rate.

Keyphrases

squamous cell carcinoma
dna damage
small cell lung cancer
cell cycle
emergency department
oxidative stress
cross sectional
cell proliferation
double blind
drug induced