ITGB4 deficiency induces DNA damage by downregulating HDAC1 in airway epithelial cells under stress stimulation.
Kun XuYe YaoHuijun LiuMing YangLin YuanXizi DuYu YangLing QinWeijie WangKai ZhouXinyu WuChi LiuPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2022)
This study confirmed the involvement of ITGB4 in the regulation of DNA damage through mediating HDAC1 in airway epithelial cells under exogenous stress. These results supply some useful insights into the mechanism of DNA damage in airway epithelial cells, which would provide possible targets for early prediction and intervention of pulmonary diseases.