Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy.

Mengjiao YangZhihui WangJin XieMd Reyad-Ul-FerdousSiying LiYongfeng Song

Published in: Chronic diseases and translational medicine (2023)

We found that the downregulation of CypD expression alleviated liver I/R injury by reducing apoptosis and autophagy through caspase-3/Beclin1 crosstalk; in contrast, the upregulation of CypD expression aggravated liver I/R injury. Therefore, interfering with the expression of CypD seems to be a promising treatment for liver I/R injury.

Keyphrases

poor prognosis
cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell cycle arrest
induced apoptosis
magnetic resonance
magnetic resonance imaging
smoking cessation
human health
contrast enhanced
pi k akt