Controlled Diesel Exhaust Exposure Induces a Concentration-Dependent Increase in Airway Inflammation.
Juma OrachChristopher Francis RiderAgnes Che Yan YuenCarley SchwartzNeeloffer MookherjeeChristopher CarlstenPublished in: Annals of the American Thoracic Society (2023)
DE induces a concentration-dependent increase in FeNO, indicating that it may be a sensitive marker of an acute inflammatory response in the airways. We report responses at concentrations below those in previous controlled DE exposure studies, and document PM2.5 concentration-response estimates at exposure levels routinely experienced in the community and occupational settings. Clinical trial registered with ClinicalTrials.gov (NCT03234790).