Tumour necrosis factor alpha and interleukin-5 inhibit olfactory regeneration via apoptosis of olfactory sphere cells in mice models of allergic rhinitis.

Dong Kyu KimSeung Ah ChoiKyoung Mi EunSeung-Ki KimDae Woo KimJi Hoon Phi

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)

Allergic rhinitis mice models showed lower expression of OSCs, and TNF-α combined with IL-5 had an apoptotic effect on OSCs. Therefore, these cytokines may be therapeutic targets for olfactory dysfunction in patients with allergic rhinitis.

Keyphrases

allergic rhinitis
cell cycle arrest
cell death
induced apoptosis
oxidative stress
high fat diet induced
endoplasmic reticulum stress
stem cells
poor prognosis
rheumatoid arthritis
type diabetes
binding protein
insulin resistance
skeletal muscle
anti inflammatory
metabolic syndrome
signaling pathway