A pilot study: Examining cytoskeleton gene expression profiles in Pakistani children with autism spectrum disorder.
Sana MalikSyed Aoun AliAhmed Murtaza MehdiAmir RazaShahid BashirDeeba Noreen BaigPublished in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2024)
Here we report the role of cytoskeleton linked genes (PFN and ERM) in co-relation to ASD. Furthermore, variable yet significant quantitative expression of these genes successfully predicted drug-gene interactions as shown with the help of connectivity maps that can be used to support the clinical use of these drugs to treat individuals with ASD in future studies.
Keyphrases
- genome wide
- genome wide identification
- gene expression
- autism spectrum disorder
- dna methylation
- attention deficit hyperactivity disorder
- genome wide analysis
- poor prognosis
- bioinformatics analysis
- intellectual disability
- transcription factor
- copy number
- high resolution
- resting state
- white matter
- drug induced
- multiple sclerosis
- adverse drug
- mass spectrometry