Clinical trajectories of hand function impairment in systemic sclerosis: an unmet clinical need across disease subsets.
Enrico De LorenzisVishal KakkarStefano Di DonatoMichelle WilsonTheresa BarnesChris DentonEmma Derrett-SmithKaren DouglasPhilip S HelliwellAriane L HerrickBenazir SaleemMuhammad NisarCatherine MorleyLorraine GreenBegonya Alcacer-PitarchFrancesco Del GaldoPublished in: RMD open (2024)
Hand function deteriorates over time in more than 50% of SSc patients despite available therapies. The analysis of factors associated with hand function worsening supports the involvement of both inflammation, vascular and fibrotic processes in hand involvement, making it a hallmark clinical manifestation of SSc. Our data are poised to inform the design of intervention studies to target this major driver of disability in SSc.
Keyphrases
- systemic sclerosis
- end stage renal disease
- interstitial lung disease
- randomized controlled trial
- oxidative stress
- newly diagnosed
- chronic kidney disease
- ejection fraction
- depressive symptoms
- machine learning
- big data
- peritoneal dialysis
- electronic health record
- artificial intelligence
- deep learning
- patient reported