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Yap1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas.

Tenny MudiantoKatie M CampbellJason WebbPaul ZolkindZachary L SkidmoreRachel RileyErica K BarnellIbrahim OzgencTusar GiriGavin P DunnDouglas R AdkinsMalachi GriffithAnn Marie EgloffMalachi GriffithRavindra Uppaluri
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
These studies identify a Yap1-dependent resistance to trametinib therapy in HNSCCs. Combined Yap1 and MEK targeting may represent a strategy to enhance HNSCC response.
Keyphrases
  • squamous cell
  • high grade
  • stem cells
  • drug delivery
  • bone marrow
  • signaling pathway