Yap1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas.
Tenny MudiantoKatie M CampbellJason WebbPaul ZolkindZachary L SkidmoreRachel RileyErica K BarnellIbrahim OzgencTusar GiriGavin P DunnDouglas R AdkinsMalachi GriffithAnn Marie EgloffMalachi GriffithRavindra UppaluriPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
These studies identify a Yap1-dependent resistance to trametinib therapy in HNSCCs. Combined Yap1 and MEK targeting may represent a strategy to enhance HNSCC response.