Palladium-catalyzed alkynylation of allylic gem -difluorides.

Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic gem -difluorides via C-F bond activation/transmetallation/β-C elimination or nucleophilic attack has been achieved. This innovative protocol showcases an extensive substrate range and operates efficiently under mild reaction conditions, resulting in high product yields and Z -selectivity. Particularly noteworthy is its exceptional tolerance towards a wide array of functional groups. This developed methodology provides effective and convenient routes to access a diverse array of essential fluorinated enynes, esters and amines.