Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review.

Jamie L FeltonKurt J GriffinRichard A OramCate Speake Sarah Alice Long Suna Onngut-Gumuscu Stephen S RichGabriela S F MonacoCarmella Evans-MolinaLinda A DiMeglioHeba M IsmailAndrea K SteckDana DabeleaRandi K JohnsonMarzhan UrazbayevaStephen GitelmanJohn M WentworthMaria J RedondoEmily K Simsnull null

Published in: Communications medicine (2023)

While the quality of prevention and intervention trials is overall high, the low quality of precision analyses makes it difficult to draw meaningful conclusions that inform clinical practice. To facilitate precision medicine approaches to T1D prevention, considerations for future precision studies include the incorporation of uniform outcome measures, reproducible biomarkers, and prespecified, fully powered precision analyses into future trial design.

Keyphrases

type diabetes
clinical practice
current status
randomized controlled trial
clinical trial
cardiovascular disease
study protocol
metabolic syndrome
phase iii
insulin resistance
phase ii