Soluble Triggering Receptors Expressed on Myeloid Cells (sTREM) in Acute Ischemic Stroke: A Potential Pathway of sTREM-1 and sTREM-2 Associated with Disease Severity.
Greta SalafiaAngelica CarandinaRoberto Maria SaccoEvelyn FerriNicola MontanoBeatrice ArosioEleonora TobaldiniPublished in: International journal of molecular sciences (2024)
In 2022, stroke emerged as the most significant cerebrovascular disorder globally, causing 6.55 million deaths. Microglia, crucial for CNS preservation, can exacerbate brain damage in ischemic stroke by triggering neuroinflammation. This process is mediated by receptors on microglia, triggering receptors expressed on myeloid cells (TREM-1 and TREM-2), which have contrasting roles in neuroinflammation. In this study, we recruited 38 patients within 4.5 h from the onset of ischemic stroke. The degree of severity was evaluated by means of the National Institutes of Health Stroke Scale (NIHSS) at admission (T0) and after one week of ischemic events (TW) and the Modified Rankin Scale (mRS) at three months. The plasma concentration of TREMs (sTREM) was analyzed by next-generation ELISA at T0 and TW. The sTREM-1 concentrations at T0 were associated with mRS, while the sTREM-2 concentrations at T0 were associated with both the NIHSS at T0 and the mRS. A strong correlation between sTREM-1 and sTREM-2 was observed, suggesting a dependent modulation of the levels. This study provides insights into the potential pathway of TREM-1 and TREM-2 as a future biomarker for stratifying high-risk patients with ischemic stroke.
Keyphrases
- atrial fibrillation
- induced apoptosis
- cerebral ischemia
- cell cycle arrest
- traumatic brain injury
- emergency department
- end stage renal disease
- dendritic cells
- inflammatory response
- public health
- healthcare
- ejection fraction
- lipopolysaccharide induced
- bone marrow
- mental health
- neuropathic pain
- lps induced
- endoplasmic reticulum stress
- human health
- cognitive impairment
- immune response
- cell proliferation
- brain injury
- randomized controlled trial
- quality improvement
- ischemia reperfusion injury
- pi k akt