Mobilizable plasmids drive the spread of antimicrobial resistance genes and virulence genes in Klebsiella pneumoniae.
Jianfeng ZhangYanping XuMeng WangXiaobin LiZhiyuan LiuDai KuangZixin DengHong-Yu OuJie-Ming QuPublished in: Genome medicine (2023)
Our work observed that a mobilizable MDR or virulence plasmid that carries oriT but lacks the relaxase genes transferred with the helper CR conjugative plasmid and mobilizable plasmids escaped from CRISPR-Cas defence and remained stable in recipients. These results highlight the threats of mobilizable plasmids as vital vehicles in the dissemination of antibiotic resistance and virulence genes in K. pneumoniae.
Keyphrases
- escherichia coli
- klebsiella pneumoniae
- antimicrobial resistance
- crispr cas
- genome wide
- multidrug resistant
- biofilm formation
- bioinformatics analysis
- genome wide identification
- staphylococcus aureus
- pseudomonas aeruginosa
- genome editing
- dendritic cells
- immune response
- transcription factor
- microbial community
- candida albicans
- antibiotic resistance genes