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Engineering the next generation of cell-based therapeutics.

Caleb J BashorIsaac B HiltonHozefa BandukwalaDevyn M SmithOmid Veiseh
Published in: Nature reviews. Drug discovery (2022)
Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. Despite notable recent clinical and commercial successes, cell-based therapies continue to face numerous challenges that limit their widespread translation and commercialization, including identification of the appropriate cell source, generation of a sufficiently viable, potent and safe product that meets patient- and disease-specific needs, and the development of scalable manufacturing processes. These hurdles are being addressed through the use of cutting-edge basic research driven by next-generation engineering approaches, including genome and epigenome editing, synthetic biology and the use of biomaterials.
Keyphrases
  • single cell
  • cell therapy
  • small molecule
  • dna methylation
  • crispr cas
  • stem cells
  • gene expression
  • bone marrow
  • risk assessment