In vitro and in silico studies of terpenes, terpenoids and related compounds with larvicidal and pupaecidal activity against Culex quinquefasciatus Say (Diptera: Culicidae).
S Andrade-OchoaJ Correa-BasurtoL M Rodríguez-ValdezL E Sánchez-TorresB Nogueda-TorresGuadalupe Virginia Nevárez-MoorillónPublished in: Chemistry Central journal (2018)
The description of the molecular properties and the structural characteristics responsible for larvicidal activity of the tested compounds were used for the development of mathematical models of structure-activity relationship. The identification of molecular and structural descriptors, as well as studies of molecular docking on the SCP-2 protein, provide insight on the mechanism of action of the active molecules, and the information can be used for the design of new structures for synthesis as potential new larvicidal agents.