MR imaging profile and histopathological characteristics of tumour vasculature, cell density and proliferation rate define two distinct growth patterns of human brain metastases from lung cancer.
Makoto KiyoseEva HerrmannJenny RoeslerPia S ZeinerJoachim P SteinbachMarie-Therese ForsterKarl H PlateMarcus CzabankaThomas J VoglElke HattingenMichel MittelbronnStella BreuerPatrick N HarterSimon BernatzPublished in: Neuroradiology (2022)
Interpretable and easy to obtain MRI features may not be sufficient to predict directly the primary tumour entity of BM but seem to have the potential to aid differentiating high- and low-proliferative BMs, such as SCLC and NSCLC.
Keyphrases
- brain metastases
- contrast enhanced
- small cell lung cancer
- magnetic resonance imaging
- endothelial cells
- single cell
- magnetic resonance
- computed tomography
- signaling pathway
- diffusion weighted imaging
- induced pluripotent stem cells
- cell therapy
- pluripotent stem cells
- stem cells
- mesenchymal stem cells
- advanced non small cell lung cancer