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The effectiveness of parenteral agents for pain reduction in patients with migraine presenting to emergency settings: A systematic review and network analysis.

Scott W KirklandLloyd VisserJillian MeyerDaniela R JunqueiraSandra CampbellCristina Villa-RoelBenjamin W FriedmanNana Owusu EsselBrian H Rowe
Published in: Headache (2024)
Various parenteral agents were found to provide effective pain relief. Considering the consistent improvements across various outcomes, combination therapy, as well as monotherapy of either metoclopramide or neuroleptics are recommended as first-line options for managing acute migraine pain. There are risks of adverse events, especially akathisia, following treatment with these agents. We recommend that a shared decision-making model be considered to effectively identify the best treatment option based on the patient's needs.
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