Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
Johann GoutLukas PerkhoferMareen MoraweFrank ArnoldMichaela IhleStephanie BiberSebastian LangeElodie RogerJohann M KrausKatja StifterStephan A HahnAndrea ZamperoneThomas EngleitnerMartin MüllerKarolin WalterEva Rodriguez-AznarBruno SainzPatrick C HermannElisabeth HessmannSebastian MüllerNinel AzoiteiAndré LechelStefan LiebauMartin WagnerDiane M SimeoneHans A KestlerThomas SeufferleinLisa WiesmüllerRoland RadPierre-Olivier FrappartAlexander KlegerPublished in: Gut (2020)
Analysis of the molecular susceptibilities triggered by ATM deficiency in PDAC allow elaboration of an efficient mutation-specific combinational therapeutic approach that can be also implemented in a genotype-independent manner by ATM inhibition.