Biological Role and Aberrant Overexpression of Syntenin-1 in Cancer: Potential Role as a Biomarker and Therapeutic Target.
Valeria Guadalupe Pintor-RomeroEdgar Hurtado-OrtegaMaría Lilia Nicolás-MoralesMayralina Gutiérrez-TorresAmalia Vences-VelázquezCarlos Ortuño-PinedaMónica Espinoza-RojoNapoleón Navarro-TitoKaren Cortés-SarabiaPublished in: Biomedicines (2023)
Syntenin-1 is a 298 amino acid protein codified by the melanoma differentiation-associated gene-9 ( MDA-9 ). Structurally, it is composed of four domains: N-terminal, PDZ1, PDZ2, and C-terminal. The PDZ domains of syntenin-1 are involved in the stability and interaction with other molecules such as proteins, glycoproteins, and lipids. Domains are also associated with several biological functions such as the activation of signaling pathways related to cell-to-cell adhesion, signaling translation, and the traffic of intracellular lipids, among others. The overexpression of syntenin-1 has been reported in glioblastoma, colorectal, melanoma, lung, prostate, and breast cancer, which promotes tumorigenesis by regulating cell migration, invasion, proliferation, angiogenesis, apoptosis, and immune response evasion, and metastasis. The overexpression of syntenin-1 in samples has been associated with worst prognostic and recurrence, whereas the use of inhibitors such as shRNA, siRNA, and PDZli showed a diminution of the tumor size and reduction in metastasis and invasion. Syntenin-1 has been suggested as a potential biomarker and therapeutic target in cancer for developing more effective diagnostic/prognostic tests or passive/active immunotherapies.
Keyphrases
- cell migration
- papillary thyroid
- amino acid
- cell proliferation
- immune response
- signaling pathway
- cell adhesion
- prostate cancer
- squamous cell
- transcription factor
- oxidative stress
- fatty acid
- endothelial cells
- copy number
- genome wide
- dna methylation
- squamous cell carcinoma
- bone marrow
- gene expression
- epithelial mesenchymal transition
- skin cancer
- air pollution
- mesenchymal stem cells
- lymph node metastasis
- cell death
- pi k akt
- free survival
- benign prostatic hyperplasia
- inflammatory response
- cancer therapy
- binding protein
- protein protein