TGF-β and BMP signaling are associated with the transformation of glioblastoma to gliosarcoma and then osteosarcoma.

Aiguo LiJohn C HancockMartha QuezadoSusie AhnNicole BricenoOrieta CelikuSurabhi RanjanOrwa AboudNicole ColwellSun A KimEdjah NduomSkyler KuhnDeric M ParkElizabeth VeraKen AldapeTerri S ArmstrongMark R Gilbert

Published in: Neuro-oncology advances (2023)

This unusual clinical case provided an opportunity to explore the modulators of longitudinal sarcomatous transformation, potentially uncovering markers indicating predisposition to this change and identification of novel therapeutic targets.

Keyphrases

small molecule
mesenchymal stem cells

transforming growth factor
cross sectional

bioinformatics analysis

signaling pathway