Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness.
Liang HanNathachit LimjunyawongFei RuZhe LiOlivia J HallHaley SteeleYuyan ZhuJulie WilsonWayne MitznerMarian KollarikBradley J UndemBrendan J CanningXinzhong DongPublished in: Nature neuroscience (2018)
Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.