Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study.
Marie CantierAdeline MorisotEmmanuel GuérotBruno MegarbaneKeyvan RazaziDamien ContouEric MariotteEmmanuel CanetEtienne De MontmollinVincent DubéeEric BouletStéphane GaudryGuillaume VoiriotJulien MayauxFrédéric PèneMathilde NeuvilleBruno MourvillierStéphane RucklyLila BouadmaMichel WolffJean-François TimsitRomain Sonnevillenull nullPublished in: Critical care (London, England) (2018)
A poor functional outcome in adult TBM patients admitted to the ICU in a nonendemic area is observed in 60% of cases and is independently associated with elevated cerebrospinal fluid protein level and hydrocephalus. Our data also suggest a protective effect of adjunctive steroids, with reduced disability and mortality, irrespective of immune status and severity of disease at presentation. One-year follow-up revealed functional independence in most survivors.
Keyphrases
- cerebrospinal fluid
- intensive care unit
- mechanical ventilation
- multiple sclerosis
- cardiovascular events
- young adults
- electronic health record
- risk factors
- single cell
- big data
- protein protein
- cross sectional
- case report
- amino acid
- type diabetes
- clinical trial
- double blind
- cardiovascular disease
- small molecule
- machine learning
- childhood cancer
- data analysis