Synergistic therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) and voluntary exercise with running wheel in a rat model of ischemic stroke.
Satoru YabunoTakao YasuharaTakayuki NagaseSatoshi KawauchiChiaki SugaharaYosuke OkazakiKakeru HosomotoSusumu SasadaTatsuya SasakiNaoki TajiriCesar V BorlonganIsao DatePublished in: Stem cell research & therapy (2023)
This study suggests that combination therapy of intracerebral transplantation SB623 cells and voluntary exercise with RW achieves robust neurological recovery and synergistically promotes endogenous neurogenesis and angiogenesis after cerebral ischemia, possibly through a mechanism involving the up-regulation of BDNF and VEGF.
Keyphrases
- cerebral ischemia
- combination therapy
- endothelial cells
- high intensity
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- vascular endothelial growth factor
- induced apoptosis
- physical activity
- resistance training
- cell therapy
- mesenchymal stem cells
- induced pluripotent stem cells
- cancer therapy
- drug delivery
- signaling pathway
- pluripotent stem cells
- cell proliferation