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Identification of key player genes in gene regulatory networks.

Maryam NazariehAndreas WieseThorsten WillMohamed HamedVolkhard Helms
Published in: BMC systems biology (2016)
This paper proposes a new method to identify key player genes in gene regulatory networks. The Java implementation of the heuristic algorithm explained in this paper is available as a Cytoscape plugin at http://apps.cytoscape.org/apps/mcds . The SageMath programs for solving integer linear programming formulations used in the paper are available at https://github.com/maryamNazarieh/KeyRegulatoryGenes and as supplementary material.
Keyphrases
  • bioinformatics analysis
  • genome wide
  • genome wide identification
  • machine learning
  • primary care
  • public health
  • quality improvement
  • genome wide analysis
  • dna methylation
  • gene expression
  • neural network