Investigation of white matter PiB uptake as a marker of white matter integrity.
Burcu ZeydanChristopher G SchwarzVal J LoweRobert I ReidScott A PrzybelskiTimothy G LesnickWalter K KremersMatthew L SenjemJeffrey L GunterHoon-Ki MinPrashanthi VemuriDavid S KnopmanRonald C PetersenClifford R JackOrhun H KantarciKejal KantarciPublished in: Annals of clinical and translational neurology (2019)
Reduced PiB uptake in the WMH is associated with a loss of WM integrity and cognitive function after accounting for the global cortical PiB uptake, suggesting that WM PiB uptake may be an early biomarker of WM integrity that precedes cognitive impairment in older adults. When using WM as a reference region in cross-sectional analysis of PiB SUVr, individual variability in WMH volume as well as age should be considered.