A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota.

Zhanzhan LiBing ZhangNing WangZhenqiang ZuoHong WeiFangqing Zhao

Published in: Gut (2022)

Our results indicated that D3 is a novel drug candidate for counteracting diet-induced obesity as a non-toxic and bioactive peptide. Targeting the UGN-GUCY2C endocrine axis may represent a therapeutic strategy for the treatment of obesity.

Keyphrases

weight loss
insulin resistance
metabolic syndrome
high fat diet induced
type diabetes
weight gain
body mass index
drug delivery
combination therapy
smoking cessation