Multinucleated giant cell reaction in lower lip squamous cell carcinoma: a clinical, morphological, and immunohistochemical study.
Hellen Bandeira de Pontes SantosMárcia Cristina da Costa MiguelLeão Pereira PintoManuel Antonio Gordón-NúñezPollianna Muniz AlvesCassiano Francisco Weege NonakaPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2017)
Multinucleated giant cell reactions may not be involved in tumor progression in lower lip SCCs. In this microenvironment, MGCs tend to exhibit a predominantly M1 phenotype and may represent a foreign body reaction to SCC keratin pearls.