Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression.
Ana Teresa PintoAna Beatriz MachadoHugo OsórioMarta Laranjeiro PintoRui VitorinoGonçalo C JustinoCátia SantaFlávia CastroTânia CruzCarla RodriguesJorge LimaJosé Luís R SousaAna Patrícia CardosoRita FigueiraArmanda MonteiroMargarida MarquesBruno ManadasJarne PauwelsKris GevaertMarc MareelSonia RochaTiago DuarteMaria José OliveiraPublished in: Cancers (2022)
Irradiated macrophages present lower ATP levels and glucose uptake, and exhibit decreased cathepsin D expression, while increasing TfR1 expression and altering iron metabolism.