RiPerC Attenuates Cerebral Ischemia Injury through Regulation of miR-98/PIK3IP1/PI3K/AKT Signaling Pathway.
Dengwen ZhangLi MeiRuichun LongCan CuiYi SunSheng WangZhengyuan XiaPublished in: Oxidative medicine and cellular longevity (2020)
Our finding indicated that RiPerC inhibited the MCAO-induced expression of PIK3IP1 through upregulated miR-98, thereby reducing the apoptosis induced by PIK3IP1 through the PI3K/AKT signaling pathway, thus reducing the cerebral ischemia-reperfusion injury.
Keyphrases
- pi k akt
- cell proliferation
- cerebral ischemia
- cell cycle arrest
- signaling pathway
- subarachnoid hemorrhage
- ischemia reperfusion injury
- long non coding rna
- oxidative stress
- brain injury
- poor prognosis
- blood brain barrier
- long noncoding rna
- diabetic rats
- induced apoptosis
- high glucose
- epithelial mesenchymal transition
- endoplasmic reticulum stress
- cell death