Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells.
Laween UthmanMarius KuschmaGregor RömerMarleen BoomsmaJens KesslerJeroen HermanidesMarkus W HollmannBenedikt PreckelCoert J ZuurbierNina C WeberPublished in: Cardiovascular drugs and therapy (2020)
Cana conveys anti-inflammatory actions in LPS-treated HCAECs through 1) reductions in HKII and ERK1/2 phosphorylation and 2) AMPK activation. These data suggest a novel anti-inflammatory mechanism of Cana through HKII.
Keyphrases
- anti inflammatory
- endothelial cells
- coronary artery
- high glucose
- protein kinase
- signaling pathway
- pulmonary artery
- inflammatory response
- toll like receptor
- vascular endothelial growth factor
- skeletal muscle
- electronic health record
- cell proliferation
- pi k akt
- big data
- lps induced
- newly diagnosed
- pluripotent stem cells
- data analysis
- artificial intelligence
- pulmonary arterial hypertension