The expression of terminal deoxynucleotidyl transferase and paired box gene 5 in Merkel cell carcinomas and its relation to the presence of Merkel cell polyomavirus DNA.

Benjamin JohanssonHelka SahiVirve S K KoljonenTom Böhling

Published in: Journal of cutaneous pathology (2018)

We observed frequent TdT and PAX5 immunoexpression in MCC tumor samples. However, simultaneous immunoexpression of these markers was scarce. TdT expression was statistically significantly associated with MCV positivity. The absence of a statistically significant association between tumor parameters and disease progression markers undermines the systemic use of these markers in clinical practice.

Keyphrases

poor prognosis
single cell
binding protein
transcription factor
high grade
stem cells
gene expression
dna methylation