Inhibition of human prostate smooth muscle contraction by the LIM kinase inhibitors, SR7826 and LIMKi3.
Qingfeng YuChristian GratzkeYiming WangAnnika HerlemannChristian Maximilian SterrBeata RutzAnna CiotkowskaXiaolong WangFrank StrittmatterChristian G StiefMartin HennenbergPublished in: British journal of pharmacology (2018)
Smooth muscle tone in the hyperplastic human prostate may underlie the effects of LIMKs, which promote contraction. Contraction of prostate strips can be inhibited by small molecule LIMK inhibitors.