The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers.
Ida TylleskärSissel SkarraArnre Kristian SkulbergOla DalePublished in: European journal of clinical pharmacology (2021)
Remifentanil increases the bioavailability of naloxone after nasal administration by reducing the pre-systemic metabolism of the swallowed part of the nasal dose.