Objective disease activity assessment and therapeutic drug monitoring prior to biologic therapy changes in routine inflammatory bowel disease clinical practice: TARGET-IBD.
Benjamin ClickEdward L BarnesBenjamin L CohenBruce E SandsJohn S HansonDavid T RubinMarla C DubinskyMiguel RegueiroDerek GazisJulie M CrawfordMillie D LongPublished in: BMC gastroenterology (2022)
Nearly one-third of patients undergoing a biologic dose change or discontinuation do not undergo objective disease activity assessment or TDM. Assessment choice differs by disease. Future studies assessing the impact of such practices on long-term outcomes are needed.