Cell-Specific Transposable Element and Gene Expression Analysis Across Systemic Lupus Erythematosus Phenotypes.

Zachary Cutts Sarah L PattersonLenka MaliskovaKimberly E TaylorChun Jimmie YeMaria Dall'EraRebecca GraingerLindsey A CriswellGabriela K FragiadakisCharles LangelierJohn A CapraMarina SirotaCristina M Lanata

Published in: ACR open rheumatology (2024)

These findings suggest that expression of TEs contributes to activation of SLE-related mechanisms in a cell-specific manner, which can impact disease diagnostics and therapeutics.

Keyphrases

systemic lupus erythematosus
single cell
cell therapy
disease activity
poor prognosis
genome wide identification
small molecule
copy number
genome wide
gene expression
stem cells
bone marrow
long non coding rna
genome wide analysis