ANGPTL4 Expression Is Increased in Epicardial Adipose Tissue of Patients with Coronary Artery Disease.
Yasufumi KatanasakaAyumi SaitoYoichi SunagawaNurmila SariMasafumi FunamotoSatoshi ShimizuKana ShimizuTakehide AkimotoChikara UekiMitsuru KitanoKoji HasegawaGenichi SakaguchiTatsuya MorimotoPublished in: Journal of clinical medicine (2022)
Epicardial adipose tissue (EAT) is known to affect atherosclerosis and coronary artery disease (CAD) pathogenesis, persistently releasing pro-inflammatory adipokines that affect the myocardium and coronary arteries. Angiopoietin-like 4 (ANGPTL4) is a protein secreted from adipose tissue and plays a critical role in the progression of atherosclerosis. Here, the expression of ANGPTL4 in EAT was investigated in CAD subjects. Thirty-four consecutive patients (13 patients with significant CAD; 21 patients without CAD) undergoing elective open-heart surgery were recruited. EAT and pericardial fluid were obtained at the time of surgery. mRNA expression and ANGPTL4 and IL-1β levels were evaluated by qRT-PCR and ELISA. The expression of ANGPTL4 ( p = 0.0180) and IL-1β ( p < 0.0001) in EAT significantly increased in the CAD group compared to that in the non-CAD group and positively correlated ( p = 0.004). Multiple regression analysis indicated that CAD is a contributing factor for ANGPTL4 expression in EAT. IL-1β level in the pericardial fluid was significantly increased in patients with CAD ( p = 0.020). Moreover, the expression of ANGPTL4 ( p = 0.004) and IL-1β ( p < 0.001) in EAT was significantly increased in non-obese patients with CAD. In summary, ANGPTL4 expression in EAT was increased in CAD patients.
Keyphrases
- coronary artery disease
- adipose tissue
- poor prognosis
- end stage renal disease
- percutaneous coronary intervention
- ejection fraction
- cardiovascular events
- newly diagnosed
- minimally invasive
- binding protein
- coronary artery bypass grafting
- chronic kidney disease
- type diabetes
- insulin resistance
- metabolic syndrome
- heart failure
- prognostic factors
- high fat diet
- cardiovascular disease
- patients undergoing
- coronary artery bypass
- coronary artery
- aortic stenosis
- bariatric surgery
- acute coronary syndrome
- atrial fibrillation
- patient reported
- obese patients
- surgical site infection
- high speed
- transcatheter aortic valve replacement
- aortic valve