Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer.

Jian XiaoShuqing CaoJiawei WangPengyu LiQuan ChengXinyi ZhouJiacheng DongYuan LiXinyu ZhaoZekuan XuLi Yang

Published in: Cancer communications (London, England) (2024)

Leptin-induced phosphorylation of ANGPTL4 facilitates LPL-mediated lipid uptake and consequently stimulates the production of PGE2, ultimately facilitating LNM in GC.

Keyphrases

lymph node metastasis
squamous cell carcinoma
fatty acid
high glucose
diabetic rats
drug induced
dna binding
oxidative stress
mass spectrometry
transcription factor
simultaneous determination