Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection.
Rania El FekihJames HurleyVasisht TadigotlaAreej AlghamdiAnand SrivastavaChristine CoticchiaJohn ChoiHazim AllosKarim YatimJuliano B AlhaddadSiawosh EskandariPhilip ChuAlbana B MihaliIsadora T LapeMauricio P Lima FilhoBruno T AoyamaAnil ChandrakerKassem SafaJames F MarkmannLeonardo V RiellaRichard N FormicaJohan SkogJamil R AzziPublished in: Journal of the American Society of Nephrology : JASN (2021)
Our findings show that mRNA signatures derived from urinary exosomes represent a powerful and noninvasive tool to screen for kidney allograft rejection. This finding has the potential to assist clinicians in therapeutic decision making.