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Inhibitory effect of all-trans retinoic acid on ferroptosis in BeWo cells mediated by the upregulation of heme Oxygenase-1.

Tomona MatsuokaKazuhiro KajiwaraTomoyuki KawasakiSeiji WadaOsamu SamuraHaruhiko SagoAikou OkamotoAkihiro UmezawaHidenori Akutsu
Published in: Placenta (2024)
ATRA pretreatment promotes BeWo cell viability by suppressing ferroptosis and upregulating HMOX1 and this can be used as a potential therapeutic strategy for addressing placental complications associated with ferroptosis.
Keyphrases
  • cell death
  • cell cycle arrest
  • induced apoptosis
  • cell proliferation
  • signaling pathway
  • poor prognosis
  • risk factors
  • endoplasmic reticulum stress
  • oxidative stress