Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: a meta-analysis.

Jinghan Jenny ChenMathura ThiyagarajahJianmeng SongClara ChenNathan HerrmannDamien GallagherMark J RapoportSandra E BlackJoel RamirezAna C AndreazzaPaul OhSusan MarzoliniSimon J GrahamKrista L Lanctôt

Published in: Alzheimer's research & therapy (2022)

Blood intracellular GSH decrease is seen in MCI, while both intra- and extracellular decreases were seen in AD. Brain GSH is decreased in AD and MCI in subgroup analysis. Potential bias and heterogeneity suggest the need for measurement standardization and additional studies to explore sources of heterogeneity.

Keyphrases

mild cognitive impairment
cognitive decline
single cell
fluorescent probe
drinking water
resting state
white matter
randomized controlled trial
functional connectivity
study protocol
phase iii